AN ARGININE-RICH MOTIF IN THE ORF2 CAPSID PROTEIN REGULATES THE HEPATITIS E VIRUS LIFECYCLE AND INTERACTIONS WITH THE HOST CELL.

An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell.

Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide.Hepatitis E is usually asymptomatic and self-limiting but it can become chronic in immunocompromised patients and is associated with increased fulminant hepatic failure and mortality rates in pregnant women.HEV genome encodes three proteins including the O

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Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-E3): study protocol [version 1; peer review: 2 approved]

Background: The population of older adults is growing in sub-Saharan Africa.Ageing exponentially increases fragility fracture risk.Of all global regions, Africa is projected to observe the greatest increase in fragility fractures.Fractures cause pain, disability and sometimes death, and management is expensive, often requiring complex healthcare de

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Viscoelastic coagulation test for liver transplantation

Coagulation and transfusion management in patients undergoing liver transplantation is challenging.Proper perioperative monitoring of hemostasis is essential to predict the risk of bleeding during surgery, to detect potential causes of hemorrhage in time, and to guide hemostatic therapy.The value of conventional coagulation test is questionable in

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